Phytocompounds of Curcuma longa extract are more effective against bacterial biofilm than pure curcumin only: An in-vitro and in-silico analysis

Bioactive compounds are the group of secondary metabolites plants that have a potent impact on antimicrobial and antibiofilm agents. Although Curcuma longa (turmeric) is well known for its activity, question arises if curcumin, primary bioactive compound only responsible it or synergistic simultaneous contribution more than one this efficacy. The research work aims to determine efficacy extract has higher potential activity purchased curcumin standard antibiotic. Present was initiated with GC-MS analysis ethanolic showed in addition methyl palmitate de-hydro zingerone had percent availability within extract. in-silico studies also when targeted upon Gram-positive biofilm-forming protein Staphylococcus aureus (3TIP), alone binding constant value -6.33 Kcal/mol but -17.811 acted association Dehydrozingerone. Similarly, constant's changed from -6.07 - 23.844 Kcal/mol, Gram-negative (3ZYB) Pseudomonas aeruginosa by palmitate, respectively. Lower minimum inhibitory concentration (MIC) effectivity reducing bacterial quorum sensing (QS) turmeric pure Curcumin indicated efficiency extract, This clearly action all imparts turmeric. result further confirmed scanning electron microscopic (SEM) studies, fluorescent FTIR EPS as well.